Obesity is a worldwide problem that also involves our country. It reduces life expectancy
and represents a high economic burden for individual and the society. A large amount of
economic and human resources has been allocated for obesity control and prevention. Obesity
is associated with the main non-transmissible diseases on this time: cardiovascular diseases,
type 2 diabetes mellitus, arterial hypertension, osteoarticular disease and some types of
cancer. The development of obesity include genetic, environmental and lifestyle factors. While
lipid accumulates into the adipocyte, it becomes in a tissue with hypertrophy and hyperplasia
and inflammatory cells infiltrate it. Although it is not known the primary stimulus that triggers
this inflammatory phenomenon, it is known this has deleterious consequences in the local and
systemic metabolism and give the obese phenotype with insulin resistance, atherogenesis
and inflammation. Glucocorticoids are steroidal hormones with multiple actions such as anti-
inflammatory properties. In obese patients, even when the plasma level of cortisol may be
normal, glucocorticoids are unable to achieve regulation of the pro-inflammatory state that
characterizes it. Bariatric surgery, along with recovering the weight, has been found to resolve
systemic inflammatory status. The relationship between bariatric surgery, weight recovery and
glucocorticoid activity has not been studied yet.
Papapietro V., K., & Guerrero P., J. . (2016). Obesidad, inflamación y glucocorticoides. Revista Hospital Clínico Universidad De Chile, 27(4), pp. 309–19. https://doi.org/10.5354/2735-7996.2016.70859
